NOTA-COG1410;2914099 - 35 - 5

1. 基本信息

• ️英文名称：NOTA-COG1410 。这里 NOTA 通常指 1,4,7 - 三氮杂环壬烷 - 1,4,7 - 三乙酸（1,4,7-Triazacyclononane-1,4,7-triacetic acid），是一种常用的金属螯合剂。COG1410 则是与之相连的特定功能部分，但目前暂未检索到关于 “COG1410” 更详细的独立定义，推测它可能是特定研发机构或研究团队赋予的编号，用于标识与之结合后具有特定生物活性或功能的分子 。
• ️中文名称：1,4,7 - 三氮杂环壬烷 - 1,4,7 - 三乙酸 - COG1410（由于 “COG1410” 含义不明，暂以这种基于英文名称直译的方式呈现中文名称，可能存在更合适的专业译名，需根据该部分的具体化学结构和功能确定） 。
• ️氨基酸序列及相关序列：从命名来看，NOTA-COG1410 并非典型的多肽类物质，不具有传统意义上由氨基酸残基组成的氨基酸序列、单字母序列和三字母序列 。它属于有机小分子与金属螯合剂结合的复合物，其结构中主要包含 NOTA 的环状结构以及与之相连的 COG1410 部分，COG1410 的结构决定了该分子的特异性功能，但目前缺乏公开资料明确其详细结构信息 。
• ️分子量：因缺乏 COG1410 的具体结构，难以精确计算分子量。仅 NOTA 的分子量约为 362.36 g/mol，加上 COG1410 部分后，整体分子量会相应增加，具体数值需在明确 COG1410 结构后通过化学计算软件或根据化学结构计算规则得出 。
• ️供应商：上海楚肽生物科技有限公司
• ️分子式：同理，由于 COG1410 结构未知，无法准确给出分子式。NOTA 的分子式为 C₁₂H₂₁N₃O₆ ，完整的 NOTA - COG1410 分子式需结合 COG1410 结构确定 。
• ️等电点：鉴于其非多肽本质且结构信息不完整，无法准确预测等电点。若 COG1410 部分含有可离子化的基团，如羧基、氨基等，会对整体分子的等电点产生影响，但在缺乏具体结构时难以判断 。
• ️CAS 号：2914099 - 35 - 5 。

2. 结构信息

The structure of NOTA-COG1410 consists of the NOTA moiety and the COG1410 moiety. The NOTA part has a cyclic structure with three nitrogen atoms in the ring, which can chelate metal ions through the lone pairs of electrons on these nitrogen atoms and the oxygen atoms of the acetic acid groups attached to the ring. The three acetic acid groups (-CH₂COOH) around the triazacyclononane ring provide multiple sites for complexing with metal ions, usually forming stable coordination bonds, and the coordination mode and stability are related to the type of metal ions and the reaction conditions. However, the specific structure of the COG1410 part is not clear. Generally, it is assumed that it is connected to the NOTA molecule through a certain chemical bond (such as an amide bond, an ester bond, etc., which needs to be determined according to the actual situation). The COG1410 part may contain functional groups such as aromatic rings, heterocyclic rings, or aliphatic chains, which endow the entire NOTA - COG1410 molecule with specific biological recognition ability or other functional characteristics. For example, if it contains an aromatic ring structure, it may participate in π - π stacking interactions with other molecules; if it contains a specific receptor - binding functional group, it can specifically target certain cells or tissues.

3. 作用机理及研究进展

NOTA - COG1410 is likely to be used in the field of nuclear medicine or targeted drug delivery. Given the common function of NOTA as a metal - chelating agent, it is highly possible that NOTA - COG1410 first chelates metal ions, such as radioactive metal ions (e.g., ⁶⁸Ga, ¹¹¹In, etc.). After chelation, the metal - labeled NOTA - COG1410 complex can use the specific recognition ability of the COG1410 part to target specific biological molecules or cells. For example, if the COG1410 part has a structure that can specifically bind to a certain receptor highly expressed on tumor cells, the metal - labeled complex can be specifically delivered to tumor cells. In the field of nuclear medicine, this can be used for imaging diagnosis. The radioactive metal ions in the complex can emit characteristic rays, and through imaging equipment such as PET (Positron Emission Tomography) or SPECT (Single - Photon Emission Computed Tomography), the location and distribution of tumor cells can be detected, providing important information for the early diagnosis of tumors. In terms of research progress, although there is a lack of a large number of public and specific research reports, similar NOTA - based targeting molecules have made certain progress in pre - clinical research. For example, some NOTA - labeled targeting ligands have shown good targeting ability and imaging effects in animal experiments, which provides a reference for the research of NOTA - COG1410. However, for NOTA - COG1410, there are still many aspects that need to be further studied, such as the optimization of the chelation efficiency with different metal ions, the improvement of the targeting specificity of the COG1410 part, and the evaluation of its pharmacokinetics and toxicity in the body.

4. 溶解保存

• ️保存条件：It is recommended to store NOTA - COG1410 in a dry environment at low temperature, preferably at - 20°C. Under such conditions, the stability of the molecule can be maintained, and possible degradation reactions such as hydrolysis and oxidation can be reduced. Avoiding light is also very important because some components in the molecule may be sensitive to light and prone to photochemical reactions, which may change the structure and properties of the molecule. Storage in a sealed container can prevent the molecule from contacting moisture and oxygen in the air, further ensuring its stability.
• ️Solubility：The solubility of NOTA - COG1410 in water is generally limited. It may be more soluble in some polar organic solvents such as dimethyl sulfoxide (DMSO) and N,N - dimethylformamide (DMF). When preparing a solution, first dissolve an appropriate amount of NOTA - COG1410 in an appropriate volume of DMSO or DMF, and fully stir or use ultrasonic treatment to promote dissolution. Before use, the solution needs to be diluted with an appropriate buffer according to experimental requirements. Commonly used buffers include phosphate - buffered saline (PBS). However, it should be noted that during the dilution process, precipitation may occur due to the change in the solvent environment. At this time, adjusting the pH value of the buffer, changing the ionic strength, or performing ultrasonic treatment again can be considered to improve the solubility.

5. 相关多肽

Although NOTA - COG1410 is not a polypeptide, in the context of related research, there may be some related biomolecules. For example, there may be polypeptides that are designed to have similar targeting functions as the COG1410 part. These polypeptides can be screened through phage display technology or other peptide library screening methods. They can specifically bind to the same target as COG1410, such as a certain receptor. Comparing the targeting efficiency and binding affinity of these polypeptides with NOTA - COG1410 can help to understand the advantages and disadvantages of different targeting strategies. In addition, some polypeptides may be designed to be conjugated with NOTA. These polypeptides can be used as carriers to improve the delivery efficiency and targeting ability of NOTA - metal ion complexes. For example, polypeptides with cell - penetrating ability can help NOTA - metal ion complexes enter cells more easily, which is of great significance for the intracellular imaging or targeted therapy of certain diseases.

6. 相关文献

Due to the limited public information on NOTA - COG1410, it is difficult to find highly relevant specific literature. However, the following literature on related fields can be used as a reference:

[1] Vries EFJ de, et al. Radiolabeled peptides in nuclear medicine imaging. Chem Soc Rev. 2014 Aug 7;43(15):5366 - 5393. This article may provide general knowledge and research progress on radiolabeled biomolecules, including the use of metal - chelating agents like NOTA in radiolabeling peptides, which can offer some reference for understanding the potential application of NOTA - COG1410 in nuclear medicine imaging.

[2] Cai W, et al. Multimodality molecular imaging of cancer. Chem Rev. 2014 Feb 5;114(3):1054 - 1105. This review article may cover the development and application of various molecular imaging agents in cancer diagnosis, which may be related to the potential role of NOTA - COG1410 in targeted imaging of tumors.

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